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Medroxyprogesterone Intramuscular Injection

Available by prescription only, medroxyprogesterone intramuscular injection is approved for preventing pregnancy and relieving the symptoms of endometrial or kidney cancer. It is a synthetic version of the progesterone hormone and is injected into a muscle. Although most people tolerate the drug well, side effects are possible and may include headaches, weight gain, and an absence of menstruation.

What Is Medroxyprogesterone Intramuscular Injection?

Medroxyprogesterone intramuscular injection (Depo-Provera®) is a prescription medication that contains medroxyprogesterone, a form of the hormone progesterone. It is approved for the following uses:
  • Preventing pregnancy
  • Relieving the symptoms of advanced endometrial cancer or kidney cancer.
Medroxyprogesterone intramuscular injection comes as a liquid that is injected into a muscle (intramuscular, or IM, injection). It is different from depo-subQ Provera 104™ (medroxyprogesterone subcutaneous injection), a medication that also contains medroxyprogesterone but is injected under the skin rather than into a muscle.
(Click What Is Medroxyprogesterone Intramuscular Injection Used For? for more information on this topic, including possible off-label uses.)

Are There Side Effects?

Just like any medicine, medroxyprogesterone intramuscular injection may cause side effects. However, not everyone who uses the drug will experience problems. In fact, most people tolerate it quite well.
If reactions do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider. Serious side effects are less common.
Common side effects of medroxyprogesterone intramuscular injection include but are not limited to:
  • Irregular menstrual periods
  • Absence of menstruation
  • Weight gain
  • Headache.
(Click Medroxyprogesterone Intramuscular Injection Side Effects to learn more, including potentially serious side effects you should report immediately to your healthcare provider.)
Last reviewed by: Kristi Monson, PharmD
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