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Metronidazole Vaginal Gel Side Effects

Common Side Effects

Metronidazole vaginal gel has been studied extensively in clinical trials. In these studies, the side effects that occurred in a group of people using the drug were carefully documented. In these studies, the most common reactions included:
  • Vaginal discharge -- in up to 12 percent of women
  • Vaginal yeast infection -- up to 10 percent
  • Irritation of the vulva or vagina -- up to 9 percent
  • Digestive discomfort -- up to 7 percent
  • Headache -- up to 5 percent
  • Nausea and/or vomiting -- up to 4 percent.
Other common side effects, occurring in 1 percent to 3 percent of people, included:
  • Pelvic discomfort
  • Unusual taste
  • Diarrhea or loose stools
  • Decreased appetite
  • Cramping.

Final Thoughts

You may experience some or none of the metronidazole vaginal gel side effects listed in this article. Unfortunately, there is no way for your healthcare provider to know beforehand if you will have problems with a medicine that you have never tried.
Therefore, make sure to let your healthcare provider know if you develop any side effects while using metronidazole vaginal gel or if something "just does not seem right." While it may not be related to the medication, your healthcare provider will be able to diagnose and treat the problem.
Last reviewed by: Kristi Monson, PharmD
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