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Drug Interactions With Mifepristone

CYP 3A4 Inhibitor Medications
The liver breaks down mifepristone using enzymes known as CYP 3A4 enzymes. Certain medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Combining mifepristone with one of these CYP 3A4 inhibitors may increase the level of mifepristone in your blood, potentially increasing your risk for side effects. Talk to your healthcare provider before taking mifepristone with a CYP 3A4 inhibitor.
Dihydroergotamine and Ergotamine
Mifepristone can increase the level of dihydroergotamine and ergotamine in your blood, potentially increasing your risk for serious side effects. In general, mifepristone should not be used in combination with these medicines, unless mifepristone is being used to end a pregnancy.
Fentanyl
Mifepristone can increase fentanyl blood levels, which could increase your risk for potentially serious side effects, including severe sedation. Talk to your healthcare provider before taking these medicines together.
Efavirenz
Mifepristone may increase the amount of efavirenz in your body, possibly increasing your risk for serious efavirenz side effects. If you take these medicines together, your healthcare provider may choose to monitor you more closely.
Hormonal Contraception
Mifepristone may decrease the effectiveness of hormonal contraception. If you are a woman of childbearing potential, you should talk to your healthcare provider about appropriate nonhormonal contraception options during mifepristone treatment. If you are using mifepristone to treat hyperglycemia due to Cushing's syndrome, it is very important to avoid pregnancy while you are taking this medicine.
Last reviewed by: Kristi Monson, PharmD
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