Advertisement

Drug Interactions With Mifepristone

QT-Prolonging Medications
Mifepristone can cause a change in the heart rhythm known as QT prolongation. Taking it with other medicines that cause QT prolongation (a certain change in the heart rhythm) may increase the risk for this life-threatening arrhythmia.
Medications That Thin the Blood
People who take certain medicines that thin the blood should not take mifepristone. Talk to your healthcare provider about this potential interaction if you currently take an anticoagulant or antiplatelet medicine.
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Mifepristone can increase the level of NSAIDs in your body, which could increase your risk for NSAID side effects. Your healthcare provider may choose to give you a lower NSAID dose if you take these medicines together.
Pimozide
Mifepristone can increase pimozide blood levels, which could increase your risk for pimozide side effects. Talk to your healthcare provider before taking these medicines together.
Quinidine
Mifepristone can increase quinidine blood levels, which could increase your risk for potentially serious side effects. Because of the risk for side effects, these medications should not be used together. Talk to your healthcare provider before taking mifepristone with quinidine.
Repaglinide
Mifepristone can increase blood levels of repaglinide. Therefore, if you take these medicines together, your healthcare provider may need to monitor you more closely and give you a lower repaglinide dosage if necessary.
Sirolimus
Mifepristone can increase the level of sirolimus in your body, possibly increasing your risk for potentially serious side effects, such as infections. In general, these medicines should not be used together, unless mifepristone is being used to end a pregnancy.
Last reviewed by: Kristi Monson, PharmD
Advertisement
Feed Your Adult ADHD Brain