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Drug Interactions With Mifepristone

If you take mifepristone with St. John's wort, certain corticosteroids, or medications that thin the blood, you could have adverse reactions. Some of the drug interactions with mifepristone could increase your risk for serious side effects or decrease the effectiveness of the medication. To help determine whether mifepristone is safe for you, your healthcare provider needs to know about all medicines and supplements you are taking.

An Overview of Mifepristone Interactions

Mifepristone (Mifeprex®, Korlym™) can potentially react with several other medications. Some of the products that may lead to mifepristone drug interactions include but are not limited to:
  • Corticosteroids, such as:
    • Betamethasone (Celestone®)
    • Cortisone
    • Dexamethasone (Decadron®)
    • Fludrocortisone (Florinef®)
    • Hydrocortisone (Cortef®)
    • Methylprednisolone (Depo-Medrol®, Medrol®)
    • Prednisolone (Orapred®, Pediapred®)
    • Prednisone
    • Triamcinolone (Kenalog®, Aristospan®)
  • CYP 3A4 inhibitor medications, such as:
  • Dihydroergotamine (Migranal®) and ergotamine (Bellamine S, Cafergot®, Ergomar®)
  • Fentanyl (Abstral®, Actiq®, Duragesic®, Fentora®, Onsolis™)
  • Efavirenz (Sustiva®)
  • Hormonal contraceptives, such as birth control pills
  • Medications that cause a certain change in the heart rhythm known as QT prolongation (see QT-Prolonging Medications for a list of such medications)
  • Medications that "thin" the blood (such as anticoagulant and antiplatelet drugs), such as:
      • Alteplase (Activase®)
      • Reteplase (Retavase®)
      • Streptokinase (Streptase®)
      • Tenecteplase (TNKase®)
  • Nonsteroidal anti-inflammatory drugs (NSAIDs), such as:

More Headlines in Drug Interactions With Mifepristone

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Last reviewed by: Kristi Monson, PharmD
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