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Mifepristone Dosage

Mifepristone Dosing for Cushing's Syndrome

The usual initial mifepristone dosage to control high blood sugar (hyperglycemia) in people with Cushing's syndrome is 300 mg once a day. Your healthcare provider may increase your dose by 300 mg every two to four weeks if you are tolerating the medicine and higher doses are needed to adequately control your symptoms.
Doses should usually not exceed 1200 mg a day or 20 mg per kg body weight (about 9.1 mg per pound). People with kidney disease or mild-to-moderate liver disease should not take more than 600 mg a day.
If you experience intolerable or potentially dangerous mifepristone side effects, your healthcare provider may reduce your dose, or recommend you stop taking the medication. If you stop the medicine, and later start taking it again, you will be restarted at the initial recommended dose of 300 mg a day, and slowly increased from there.

General Information on Taking Mifepristone

Some considerations to keep in mind during treatment with mifepristone include the following:
  • This medication comes in tablet form. It is usually taken by mouth as a single dose to end a pregnancy. When used in people with Cushing's syndrome, it is usually taken once a day.
  • If you are taking this medication for diabetes or glucose intolerance, you should take it with food.
  • If you are taking mifepristone every day, try to take your dose at the same time each day to keep an even level of the drug in your bloodstream.
  • Mifepristone 300 mg tablets should be swallowed whole. Do not cut, crush, or chew the tablets.
  • When used to end a pregnancy, mifepristone should only be taken in a healthcare setting, such as a clinic, medical office, or hospital. You will need to visit your healthcare provider three times so your healthcare provider can make sure your pregnancy has ended.
  • If mifepristone does not end your pregnancy, you will be given another medicine (misoprostol) two days after taking mifepristone.
  • For the medication to work properly, it must be taken as prescribed.
  • If you are unsure about anything related to your dosage or mifepristone dosing in general, please talk to your healthcare provider or pharmacist.
Last reviewed by: Kristi Monson, PharmD
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