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Mifepristone Side Effects

Common Side Effects

Mifepristone has been studied extensively in clinical trials. In these studies, the side effects that occurred in a group of people taking mifepristone were carefully documented, so it was possible to see what side effects were reported and how often they occurred.
In these studies, the most common side effects of mifepristone included the following:
  • Abdominal (stomach) pain -- in up to 96 percent of people
  • Vaginal bleeding -- up to 90 percent
  • Uterine cramping -- up to 83 percent
  • Nausea -- up to 61 percent
  • Fatigue -- up to 48 percent
  • Headache -- up to 44 percent
  • Overgrowth of the lining of the uterus (endometrial hypertrophy) -- up to 38 percent
  • Low blood potassium levels -- up to 34 percent
  • Joint pain -- up to 30 percent
  • Vomiting -- up to 26 percent
  • Swelling of the arms, hands, legs, ankles, or feet -- up to 26 percent
  • High blood pressure (hypertension) -- up to 24 percent
  • Dizziness -- up to 22 percent.

Other side effects, reported in 1 percent to 20 percent of people, included:

  • Decreased appetite
  • Diarrhea
  • General pain
  • Muscle pain
  • Dry mouth
  • Severe or abnormal vaginal bleeding
  • Fever
  • Infections
  • Shortness of breath
  • Vaginal and pelvic inflammation
  • Chills and shaking
  • Heartburn and indigestion
  • Constipation
  • Drowsiness
  • Insomnia
  • Weakness or lack of energy
  • Back pain
  • Arm and leg pain
  • Abdominal pain (stomach pain)
  • Anxiety
  • Anemia (low levels of red blood cells)
  • Vaginal discharge
  • Sinus congestion
  • Pelvic pain
  • Thirst
  • General feelings of discomfort or illness
  • Fainting.
Last reviewed by: Kristi Monson, PharmD
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