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Mifepristone Side Effects

Most women who take mifepristone will experience some type of side effect. Clinical studies have shown that some of the most common side effects of this drug include nausea, uterine cramping, and abdominal pain. It is also important to be aware of serious reactions that may occur with this drug, such as persistent fever or heavy bleeding, and when to contact a healthcare provider.

An Introduction to Side Effects of Mifepristone

Just like any medicine, mifepristone (Mifeprex®, Korlym™) can cause side effects. In fact, most people who take the medication will experience some type of side effect. However, in most cases, the side effects are minor and either require no treatment or are treated easily by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with mifepristone. Your healthcare provider can discuss a more complete list with you.)

Serious Mifepristone Side Effects

Some side effects of mifepristone are potentially serious and should be reported immediately to your healthcare provider. These include but are not limited to:
  • Signs of an allergic reaction, such as:
    • An unexplained rash
    • Hives
    • Itching
    • Unexplained swelling, especially of the mouth, lips, or throat
    • Wheezing
    • Difficulty breathing or swallowing
  • Signs of adrenal insufficiency (not enough adrenal hormones), such as:
    • Unusual fatigue or tiredness
    • Nausea
    • Loss of appetite
    • Dizziness
  • Muscle weakness or cramping
  • An abnormal, racing, or forcefully beating heart
  • Unexplained weight gain or swelling of the arms or legs, ankles, or feet
  • Signs of thyroid problems, such as:
    • Unusual tiredness
    • Increased sensitivity to cold
    • Dry skin
    • Weight gain
    • Constipation
    • Brittle hair and nails
  • Prolonged, heavy vaginal bleeding (soaking through two full-thickness pads within an hour for at least two consecutive hours)
  • A persistent fever over 100.4°F, which lasts for over four hours
  • Signs of infection, such as:
    • Abdominal (stomach) pain or discomfort
    • Severe pelvic tenderness
    • Weakness
    • Nausea
    • Vomiting
    • Diarrhea that lasts longer than 24 hours after taking mifepristone.

More Headlines in Mifepristone Side Effects

‣ Common Side Effects
‣ Final Thoughts
Last reviewed by: Kristi Monson, PharmD
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