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Precautions and Warnings With Mifepristone

Because mifepristone is not appropriate for certain people, your healthcare provider needs to know about your complete medical history and current medications before prescribing this drug. In order to take mifepristone safely, warnings and precautions for the drug should be fully discussed with your healthcare provider. Some people, such as those who have certain adrenal gland problems or bleeding problems, should not take mifepristone.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking mifepristone (Mifeprex®, Korlym™) if you have:
  • Liver disease, such as cirrhosis, liver failure, or hepatitis
  • Kidney disease, such as kidney failure (renal failure)
  • Been taking medicines known as corticosteroids for other serious medical problems
  • Had an organ transplant
  • Problems with your adrenal glands
  • An intrauterine device (IUD) in place
  • A bleeding disorder
  • Unexplained vaginal bleeding
  • Cancer of the lining of the uterus (endometrial cancer)
  • Porphyria (an inherited disorder that affects the nervous system and skin)
  • Anemia
  • Overgrowth or thickening of the lining of the uterus (endometrial hyperplasia)
  • Low levels of potassium in your blood
  • An irregular heart rhythm (arrhythmia) called QT prolongation
  • Heart disease
  • High blood pressure
  • Lung disease
  • Diabetes
  • Thyroid problems, such as an under- or overactive thyroid (hyper- or hypothyroidism)
  • Any allergies, including to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • A heavy smoker (smoke 10 or more cigarettes a day)
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
You should also tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
Last reviewed by: Kristi Monson, PharmD
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