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Drug Interactions With Milnacipran

Drug Interactions With Milnacipran Explained

The following sections explain in detail the potentially negative interactions that can occur when milnacipran is combined with any of the drugs listed above.
Alcohol
You should not drink substantial amounts of alcohol while taking milnacipran. Heavy alcohol consumption may increase the risk of liver problems.
Clonidine
Milnacipran may decrease the effectiveness of clonidine for lowering blood pressure. Check with your healthcare provider before taking these medications together.
Digoxin
In general, digoxin and milnacipran should not be taken together, as doing so increases the risk of low blood pressure (hypotension) and a rapid heart rate (tachycardia).
Epinephrine or Norepinephrine
Taking milnacipran with epinephrine or norepinephrine can cause high blood pressure (hypertension) or an irregular heart rhythm (arrhythmia). If you are taking milnacipran, your healthcare provider will need to take this into consideration before deciding to prescribe or administer epinephrine or norepinephrine.
Intravenous Methylene Blue
Taking milnacipran with intravenous methylene blue can increase your chance of developing dangerous side effects, including serotonin syndrome. This drug should not be started in people taking IV methylene blue, but a person already taking milnacipran may be given IV methylene blue, if absolutely necessary, and only with very careful monitoring and only if milnacipran is stopped during treatment.
 
Linezolid
Taking milnacipran with linezolid can increase your chance of developing dangerous side effects, including serotonin syndrome. This drug should not be started in people taking linezolid, but a person already taking milnacipran may be given linezolid, if absolutely necessary, and only with very careful monitoring and only if milnacipran is stopped during treatment.
Last reviewed by: Kristi Monson, PharmD
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