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Side Effects of Milnacipran

Common Side Effects of Milnacipran

Milnacipran has been studied extensively in clinical trials. In these studies, side effects occurring in the group of people taking the drug were documented and compared to the side effects that occurred in a similar group of people taking a placebo (a "sugar pill" with no active ingredients).
Based on these studies, the most common bothersome (but usually not dangerous) side effects included:
Other common milnacipran side effects (occurring in 2 to 10 percent of people) included:
  • Blurred vision
  • Dry mouth
  • Vomiting
  • Abdominal pain (stomach pain)
  • Chills
  • Upper respiratory tract infections (such as the common cold)
  • Decreased appetite (which may result in weight loss)
  • Migraines
  • Unusual sensations, such as numbness or tingling, or reduced sensation of touch
  • Shakiness (tremor)
  • Increased sweating
  • Flushing (redness of the face and neck).

Urinary or Sexual Side Effects Seen With Milnacipran

The prescribing information for milnacipran lists several urinary or sexual side effects, which were reported in at least 2 percent of men taking the medication for fibromyalgia (and which occurred more frequently with milnacipran compared to a placebo). The exact percentages of these side effects were not reported. Such side effects of milnacipran include:
  • Painful urination, difficulty passing urine or emptying the bladder, or decreased urine flow
  • Ejaculation problems
  • Erectile dysfunction (also known as ED or impotence)
  • Decreased sex drive
  • Infection or inflammation of the prostate (prostatitis)
  • Scrotal pain or testicular pain
  • Testicular swelling.
Last reviewed by: Kristi Monson, PharmD
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