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Nortrel Drug Interactions

Cyclosporine (Gengraf, Neoral, Sandimmune)
Nortrel may increase the level of cyclosporine in your blood, increasing the chance of side effects of cyclosporine. Talk with your healthcare provider before taking these medications together. You may need a lower cyclosporine dose, or you may need to switch to a different method of contraception.
Dexamethasone (Decadron)
Combining dexamethasone with Nortrel may increase your risk of pregnancy. Check with your healthcare provider before taking these medications together, as you may need to use a backup method of birth control.
Modafinil (Provigil)
Modafinil can make Nortrel less effective, increasing your risk of pregnancy. Talk with your healthcare provider, as you may need to use a backup method of contraception.
Protease Inhibitors
Using Nortrel together with a protease inhibitor may increase your risk of pregnancy and can make the protease inhibitor less effective. Talk with your healthcare provider before using Nortrel with a protease inhibitor.
Selegiline (Eldepryl, Emsam, Zelapar)
The hormones in Nortrel may increase the level of selegiline in your blood, increasing your risk of side effects. Your healthcare provider may need to lower your selegiline dosage or may recommend an alternate form of contraception.
St. John's Wort
St. John's wort (a commonly used herbal supplement) can decrease the effectiveness of Nortrel, increasing the chance of pregnancy. In general, you should not take St. John's wort while using Nortrel.
Various Anticonvulsants (Seizure Medications)
Some seizure medications may cause your body to metabolize the hormones in Nortrel too quickly, increasing your risk of pregnancy. Ask your healthcare provider if you should use a different method of contraception while taking a seizure medication.
Last reviewed by: Kristi Monson, PharmD
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