Nortrel Drug Interactions

Antibiotics, barbiturates, and several seizure medications are some of the medicines that can interfere with Nortrel. Drug interactions such as these can increase your risk of pregnancy and side effects. To avoid these complications, talk with your healthcare provider about possible Nortrel drug interactions before you start any other medication.

An Introduction to Nortrel Drug Interactions

Nortrel® (norethindrone and ethinyl estradiol) can potentially interact with numerous other medicines. Many of these interactions can lead to accidental pregnancy, and a backup method of birth control may be recommended in some situations. Most women have heard about such interactions between birth control pills and antibiotics, but there are several other medications that can cause problems as well.
Because many medications interact with Nortrel, you should make sure that all of your healthcare providers know that you are taking Nortrel. Any time you start a new medication, check with your healthcare provider about possible interactions with Nortrel. Some of the medicines that may lead to Nortrel interactions include:
  • Aminoglutethimide (Cytadren®)
  • Antibiotics
  • Aprepitant (Emend®)
  • Barbiturates, including, but not limited to:


    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Primidone (Mysoline®)
    • Secobarbital (Seconal®)



Last reviewed by: Kristi Monson, PharmD
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