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NuvaRing Drug Interactions

Modafinil (Provigil)
Modafinil may make NuvaRing less effective, increasing your risk of pregnancy. Talk with your healthcare provider about this possible interaction, as you may need to use a backup method of contraception.
Nafcillin (Nallpen, Unipen)
Nafcillin may cause your body to metabolize the hormones in NuvaRing too quickly, increasing your risk of pregnancy. Ask your healthcare provider if you should use a backup method of contraception.
Protease Inhibitors
Using NuvaRing with a protease inhibitor may increase your risk of pregnancy or side effects. Talk with your healthcare provider before taking these medications together.
Rifamycin Antibiotics
Rifamycin antibiotics may make NuvaRing less effective, increasing your risk of pregnancy. Talk with your healthcare provider before taking these medications together, as you may need to use an alternate form of birth control.
Selegiline (Eldepryl, Emsam, Zelapar)
The hormones in NuvaRing may increase the level of selegiline in your blood, increasing your risk of side effects. Your healthcare provider may need to lower your selegiline dosage or may recommend an alternate form of contraception.
St. John's Wort
St. John's wort, a commonly used herbal supplement, may decrease the effectiveness of NuvaRing, increasing the chance of pregnancy. In general, you should not take St. John's wort while using this birth control drug.
Warfarin (Coumadin, Jantoven)
NuvaRing may make warfarin less effective. In addition, warfarin is often used to treat blood clotting disorders, and NuvaRing is not recommended for women with such disorders because it may increase the risk of blood clots.
Last reviewed by: Kristi Monson, PharmD
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