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Nystatin and Pregnancy

No adequate studies have been conducted on pregnancy and nystatin. One survey-type study suggested a possible link between the use of the medication during the first trimester and birth defects. Since nystatin is very poorly absorbed into the bloodstream, however, it is not expected that a fetus would be exposed to the medication.

Can I Take Nystatin Safely While Pregnant?

Nystatin is a prescription antifungal medication approved to treat Candida fungal infections. It comes in a variety of different forms, including various skin products as well as products that are taken by mouth or used vaginally. At this time, it is unknown if this product is safe for use during pregnancy.

Pregnancy Category C

The U.S. Food and Drug Administration (FDA) uses a pregnancy category system to classify the possible risks to a fetus when a specific medicine is taken during pregnancy. Pregnancy Category C is given to medicines that have not been studied in pregnant humans but do appear to cause harm to the fetus in animal studies. Also, medicines that have not been studied in any pregnant women or animals are automatically given a pregnancy Category C rating.
This drug has not been adequately studied in pregnant animals or women. One survey-type study suggested a possible link between nystatin use during the first trimester and birth defects. However, it is thought that the problems resulted most likely because nystatin was often used in combination with tetracycline (an antibiotic that has a more definite link with birth defects).
However, logically, this antifungal is not expected to cause problems during pregnancy. It is very poorly absorbed into the bloodstream (even when taken by mouth, but especially when applied to the skin), and it is not expected that the fetus would be exposed to the medication. However, since the medication has not been thoroughly studied in pregnant women, the possibility of problems cannot be entirely ruled out.

More Headlines in Nystatin and Pregnancy

‣ Pregnancy and Nystatin: Final Thoughts
Last reviewed by: Kristi Monson, PharmD
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