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Ogen Vaginal Cream Warnings and Precautions

Specific Precautions and Warnings With Ogen Vaginal Cream

Warnings and precautions to be aware of prior to using Ogen Vaginal Cream include the following:
  • It is important to understand that even though Ogen Vaginal Cream is applied vaginally, the estrogen hormone in the cream is absorbed into the bloodstream. This means that any of the risks associated with oral estrogen hormone replacement therapy also apply to Ogen Vaginal Cream. Although the risks are thought to be lower with Ogen Vaginal Cream, since the body is exposed to less of the hormone, the risk is not eliminated.
  • Studies have shown that estrogen hormone replacement therapy increases the risk of strokes and blood clots in the legs. Your healthcare provider should make sure you are appropriately treated for any risk factors for heart disease or blood clots before you take Ogen Vaginal Cream. Risk factors include:
  • Let your healthcare provider know if you have abnormal vaginal bleeding (such as heavy bleeding or bleeding between periods) while using Ogen Vaginal Cream, as this may be a sign of precancerous or cancerous changes in the uterus. Your healthcare provider can perform the necessary tests to rule out cancer. Of course, if you have had a hysterectomy, you are not at risk for uterine cancer. Adding a progestin medication significantly reduces the risk of this type of cancer due to estrogen medications.
  • Estrogen drugs (such as Ogen Vaginal Cream) may increase the risk of breast cancer. Proper screening and monitoring as determined by your healthcare provider, such as yearly mammograms and monthly self breast exams, is recommended.
  • Women who take estrogens have an increased risk for gallbladder disease.
  • Ogen Vaginal Cream can cause high triglycerides in some women. Your healthcare provider should monitor you for this problem during treatment.
  • If you have an underactive thyroid (hypothyroidism), Ogen Vaginal Cream may increase your body's requirement for thyroid hormones. Your healthcare provider should monitor you closely and adjust the dose of your thyroid medications as necessary.
  • Ogen Vaginal Cream can cause fluid retention. This can cause problems for people with congestive heart failure (CHF) or kidney problems.
  • It is not clear whether estrogens (such as the one in Ogen Vaginal Cream) increase the risk of ovarian cancer. Some studies have shown an increased risk, while others have not.
  • Ogen Vaginal Cream can make endometriosis symptoms worse.
  • The cream can theoretically interact with a number of different medications (see Ogen Vaginal Cream Drug Interactions).
  • Ogen Vaginal Cream should not be used during pregnancy (see Ogen Vaginal Cream and Pregnancy).
  • The hormone in Ogen Vaginal Cream enters the bloodstream and passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to using the drug (see Ogen Vaginal Cream and Breastfeeding).
Last reviewed by: Kristi Monson, PharmD
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