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Drug Interactions With Orally Disintegrating Phentermine

Medications Used to Treat Diabetes
Because you will be eating less, your healthcare provider may need to adjust the dose of your diabetes medicines while you are using orally disintegrating phentermine.
Monoamine Oxidase Inhibitors (MAOIs)
Combining orally disintegrating phentermine with an MOAI can cause life-threatening side effects, including dangerously high blood pressure (this is known as a hypertensive crisis). You should not use orally disintegrating phentermine if you are taking an MAOI or if you have taken one in the past 14 days.
Other Weight Loss Medications
Orally disintegrating phentermine has not been adequately studied in combination with other weight loss medicines, and should generally not be combined with these products. This includes prescription, nonprescription, and herbal weight loss medicines.
Topiramate
Topiramate may increase the level of orally disintegrating phentermine in the bloodstream, perhaps increasing the risk for side effects. Sometimes, these medications are combined intentionally for weight loss. However, always check with your healthcare provider before doing this, particularly if the medications were prescribed by different healthcare providers or for different medical conditions.

Final Thoughts

It is possible that not all drug interactions with orally disintegrating phentermine were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about the specific interactions that may apply to you.
Last reviewed by: Kristi Monson, PharmD
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