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Ortho Tri-Cyclen Drug Interactions

Ortho Tri-Cyclen Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Ortho Tri-Cyclen is combined with any of the drugs listed above.
Aminoglutethimide (Cytadren)
Taking Ortho Tri-Cyclen and aminoglutethimide together increases the risk of pregnancy. Do not use these medications together without checking with your healthcare provider first. You may need to use a backup method of contraception, such as condoms.
Antibiotics
There have been reports of accidental pregnancy occurring in women taking birth control pills with certain antibiotics. It is still uncertain how significant the interaction between birth control pills and antibiotics may be. Some antibiotics are more likely to cause problems than others. Ask your healthcare provider if you need a backup method of contraception any time you take an antibiotic.
Aprepitant (Emend)
Aprepitant may make Ortho Tri-Cyclen less effective, perhaps increasing your chance of pregnancy. Talk with your healthcare provider before using these medications together. You may need to use a backup method of contraception.
Atorvastatin (Lipitor)
Atorvastatin may increase the level of Ortho Tri-Cyclen in your blood, which may increase your risk of Ortho Tri-Cyclen side effects. Check with your healthcare provider before taking these medications together.
Barbiturates
Barbiturates may cause your body to metabolize the hormones in Ortho Tri-Cyclen too quickly, possibly increasing your risk of pregnancy. Ask your healthcare provider if you should use a different method of contraception while taking a barbiturate.
Cyclosporine (Gengraf, Neoral, Sandimmune)
Ortho Tri-Cyclen may increase the level of cyclosporine in your blood, possibly increasing the chance of side effects of cyclosporine. Talk with your healthcare provider before taking these medications together. Your cyclosporine dose may need to be reduced, or you may need to switch to a different method of contraception.
Last reviewed by: Kristi Monson, PharmD
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