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Ortho Tri-Cyclen Drug Interactions

If barbiturate medications, theophylline, or protease inhibitors are taken with Ortho Tri-Cyclen, drug interactions could occur. These potentially negative interactions may increase your chance of pregnancy or increase your risk of developing side effects. Other medicines that may cause drug interactions with Ortho Tri-Cyclen include antibiotics, atorvastatin, cyclosporine, and aprepitant.

An Introduction to Ortho Tri-Cyclen Drug Interactions

Ortho Tri-Cyclen® (norgestimate/ethinyl estradiol) can potentially interact with numerous other medicines. Many of these interactions can be severe enough to cause accidental pregnancy, and a backup method of birth control may be recommended. If you are ever unsure what to do about an Ortho Tri-Cyclen drug interaction, be sure to use backup birth control until you can speak with your healthcare provider. Some of the medicines that may lead to Ortho Tri-Cyclen drug interactions include:
  • Aminoglutethimide (Cytadren®)
  • Antibiotics
  • Aprepitant (Emend®)
  • Atorvastatin (Lipitor®) or combination medications that contain atorvastatin (Caduet®, Liptruzet™)
  • Barbiturate medications, such as:
    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)
(Ortho Tri-Cyclen is equivalent to Norgestimate and Ethinyl Estradiol, Tri-Estarylla™, Tri-Linyah™, Tri-Sprintec®, TriNessa®, and Tri-Previfem® birth control pills. The information in this article also applies to each of these medications.)
Last reviewed by: Kristi Monson, PharmD
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