You may experience some or none of the Ortho Tri-Cyclen side effects listed in this article. Unfortunately, it can be difficult to tell whether any particular side effect (such as nausea) is caused by Ortho Tri-Cyclen or other factors. Therefore, make sure to let your healthcare provider know if you develop any side effects while taking the drug or if something "just does not seem right." While it may not be a side effect of Ortho Tri-Cyclen, your healthcare provider will be able to diagnose and treat the problem.