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Drug Interactions With Ospemifene

More Detail on Drug Interactions With Ospemifene

The following sections explain in detail the potentially negative interactions that can occur when ospemifene is combined with any of the drugs listed above.
 
CYP 2C9 Inducer Medications
The liver breaks down ospemifene using enzymes known as CYP 2C9 enzymes, and medications known as CYP 2C9 inducers can increase the activity of these enzymes. Thus, combining ospemifene with one of these drugs may decrease the level of ospemifene in your body, possibly making it less effective.
 
CYP 2C9 Inhibitor Medications
The liver breaks down ospemifene using enzymes known as CYP 2C9 enzymes, and medications known as CYP 2C9 inhibitors can decrease the activity of these enzymes. Thus, combining ospemifene with one of these drugs may increase the level of ospemifene in your body, increasing your risk for side effects. Your healthcare provider may monitor you more closely if you take these medications together.
 
CYP 3A4 Inducer Medications
The liver breaks down ospemifene using enzymes known as CYP 3A4 enzymes, and medications known as CYP 3A4 inducers can increase the activity of these enzymes. Thus, combining ospemifene with one of these drugs may decrease the level of ospemifene in your body, which could make it less effective.
 
CYP 3A4 Inhibitor Medications
The liver breaks down ospemifene using enzymes known as CYP 3A4 enzymes, and medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Thus, combining ospemifene with one of these drugs may increase the level of ospemifene in your body, increasing your risk for side effects. Your healthcare provider may monitor you more closely if you take these medicines together.
 
Diazepam
Combining ospemifene with diazepam may increase your blood levels of either of these medications, potentially increasing your risk for side effects. Talk to your healthcare provider before taking these medicines together.
 
Estrogen Medicines
Ospemifene works like estrogen in some ways and like an anti-estrogen in other ways. It is unknown at this time whether combining it with estrogen medicines would increase the risk for side effects. Therefore, it is generally advised that ospemifene not be taken with an estrogen.
 
Fluconazole
Fluconazole has been shown to significantly increase blood levels of ospemifene, which could increase the risk for side effects. The manufacturer of ospemifene recommends it not be taken with fluconazole.
 
Raloxifene
Both raloxifene and ospemifene belong to a group of medicines known as estrogen receptor modulators. Estrogen receptor modulators act like estrogens in some ways and like anti-estrogens in other ways. At this time, it is not known whether taking ospemifene with raloxifene would increase the risk for side effects. However, because they work in the same way, it is generally advised that these drugs not be taken together.
 
Valproate Medications
Combining ospemifene with valproate medicines could increase blood levels of either of these medicines, which could increase your risk for side effects. Talk to your healthcare provider before taking these drugs together.
 
Warfarin
It is not entirely known at this time whether ospemifene interacts with warfarin. If you take warfarin, your healthcare provider may choose to monitor you more closely by checking your international normalized ratio (INR), especially when you start or stop taking ospemifene.
 

More Headlines in Drug Interactions With Ospemifene

↶ An Overview of Ospemifene Interactions
‣ Final Thoughts
Last reviewed by: Kristi Monson, PharmD
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