Ospemifene Dosage

The standard dosage of ospemifene is 60 mg taken once a day to treat painful intercourse in women who have gone through menopause. Your healthcare provider will evaluate you periodically to determine how long you need to use this medicine. In general, you should only use it for the shortest amount of time necessary.


An Introduction to Your Dosage of Ospemifene

There is only one standard recommended dose of ospemifene (Osphena™), regardless of your age, weight, or other medical conditions. As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.

Recommended Ospemifene Dosing Guidelines

The recommended ospemifene dosage for treating painful intercourse due to vaginal changes from menopause is 60 mg taken once a day. Your healthcare provider will periodically assess your continued need for this drug and weigh the benefits of treatment against the risks. In general, ospemifene should be used for the shortest amount of time needed.
Ospemifene works like estrogen on vaginal tissue and, therefore, can cause the lining of the uterus (the endometrium) to grow and thicken. This could increase the risk for cancer of the uterine lining (known as endometrial cancer). If you have a uterus (you have not had a hysterectomy), your healthcare provider may recommend you take a progestin in addition to ospemifene. Adding a progestin may help prevent the endometrium from thickening, which may reduce the risk for developing endometrial cancer.

General Information on Taking Ospemifene

Some considerations to keep in mind during treatment with ospemifene include the following:
  • This medication comes in tablet form. It is taken by mouth once a day.
  • You should take ospemifene with food.
  • You can take ospemifene any time of day. Try to take your dose at about the same time each day, however, to keep an even level of the medication in your blood.
  • For the medication to work properly, it must be taken as prescribed.
  • If you are unsure about anything related to your ospemifene dosage, please talk with your healthcare provider, nurse, or pharmacist.
Last reviewed by: Kristi Monson, PharmD
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