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Drug Interactions With Paroxetine Mesylate Capsules

More Detail on Drug Interactions With Paroxetine Mesylate Capsules

The following sections explain in detail the potentially negative reactions that can occur when paroxetine mesylate capsules are combined with any of the drugs listed above.
 
Atomoxetine
Paroxetine mesylate capsules can increase blood levels of atomoxetine, potentially increasing your risk for atomoxetine side effects. Your healthcare provider may choose to give you a lower atomoxetine dose if you take these medications together.
 
Certain Arrhythmia Medicines
Taking paroxetine mesylate capsules with certain arrhythmia medications can increase the level of the arrhythmia medication in your blood, potentially increasing your risk of side effects. Some arrhythmia medicines can also increase blood levels of paroxetine mesylate capsules. Your healthcare provider may need to monitor you more closely if you take these medicines together.  
 
Cimetidine
Cimetidine can increase the level of paroxetine mesylate capsules in your blood, potentially increasing your risk for side effects. Your healthcare provider may need to monitor you more closely if you take these medicines together.
 
Digoxin
Taking paroxetine mesylate capsules and digoxin together may decrease the level of digoxin in your blood. If you take these medications together, your healthcare provider may need to monitor your digoxin blood levels, and adjust your dose if needed.
 
Diuretics
Paroxetine mesylate capsules can cause low blood sodium levels (known medically as hyponatremia). Taking the medicine with a diuretic may increase your risk for this side effect. Talk to your healthcare provider before taking these medications together.
 
Fosamprenavir
Fosamprenavir may decrease the level of paroxetine mesylate capsules in your blood, potentially making them less effective. Your healthcare provider may need to monitor you more closely if you take these medicines together.
 
Medications That Thin the Blood
Taking paroxetine mesylate capsules with medications that increase the risk for bleeding can further increase your risk for dangerous internal bleeding. Talk to your healthcare provider before taking these medications together. Contact your healthcare provider if you develop any signs of bleeding while taking paroxetine mesylate capsules, such as:
 
  • Weakness
  • Abdominal (stomach) pain
  • Black, tarry stools
  • Vomit that looks like coffee grounds.
 
Monoamine Oxidase Inhibitors (MAOIs)
Taking an MAOI with paroxetine mesylate capsules can cause a life-threatening side effect known as serotonin syndrome. Serotonin syndrome can lead to a variety of serious symptoms, such as agitation, hallucinations, a fast heartbeat, sweating, muscle spasms, and seizures (see Warnings and Precautions With Paroxetine Mesylate Capsules for more symptoms of serotonin syndrome). You should not take paroxetine mesylate capsules and an MAOI together, or within 14 days of one another.
 
Other Forms of Paroxetine
Paroxetine mesylate capsules contain the active ingredient paroxetine, and should not be taken with other medications that contain paroxetine. Taking these medicines together could lead to a paroxetine overdose and potentially serious side effects.
 
Other Medications That Affect Serotonin
Taking paroxetine mesylate capsules with other medications that increase serotonin levels could cause a rare but life-threatening reaction known as serotonin syndrome. Serotonin syndrome can lead to a variety of serious symptoms, such as headaches, nausea, sweating, and dizziness (see Warnings and Precautions With Paroxetine Mesylate Capsules for more symptoms of serotonin syndrome). Talk to your healthcare provider before taking these medications together. In many cases, such combinations may still be recommended, although with more careful monitoring.
 
Phenobarbital
Phenobarbital may decrease blood levels of paroxetine mesylate capsules, potentially making them less effective. Your healthcare provider may need to monitor you more closely if you take these medicines together.
 
Phenothiazine
Paroxetine mesylate capsules can increase blood levels of phenothiazine, potentially increasing your risk for side effects. Your healthcare provider may need to monitor you more closely if you take these medicines together. It is recommended that paroxetine mesylate capsules not be taken in combination with phenothiazine thioridazine.
 
Phenytoin
Phenytoin may decrease blood levels of paroxetine mesylate capsules, potentially making them less effective. Your healthcare provider may need to monitor you more closely if you take these medicines together.
 
Pimozide
Taking pimozide with paroxetine mesylate capsules could increase blood levels of pimozide and cause a dangerous irregular heart rhythm (arrhythmia) called QT prolongation. In general, these medicines should not be taken together.
 
Risperidone
Paroxetine mesylate capsules can increase the level of risperidone in your blood, potentially increasing your risk of side effects. Your healthcare provider may need to decrease your risperidone dose if you take these medicines together.
 
Ritonavir
Ritonavir may decrease the level of paroxetine mesylate capsules in your blood, potentially making them less effective. Your healthcare provider may need to monitor you more closely if you take these medicines together.
 
Tamoxifen
Paroxetine mesylate capsules may decrease blood levels of tamoxifen, which could make it less effective. Talk to your healthcare provider about this potential interaction before taking these medicines together.
 
Theophylline
Paroxetine mesylate capsules can increase the level of theophylline in your blood, potentially increasing your risk for side effects. Your healthcare provider may need to decrease your theophylline dose if you take these medicines together.
 
Tricyclic Antidepressants
Taking paroxetine mesylate capsules with a tricyclic antidepressant can increase the level of the tricyclic antidepressant in your blood. Your healthcare provider may need to reduce your tricyclic antidepressant dose if you take these medicines together.
 

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‣ Final Thoughts
Last reviewed by: Kristi Monson, PharmD
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