Paroxetine Mesylate Capsules

Important Information for Your Healthcare Provider

You should talk with your healthcare provider prior to taking this medication if you have:
  • Kidney disease, such as kidney failure (renal failure)
  • Liver disease, such as hepatitis, cirrhosis, or liver failure
  • Ever had a seizure
  • Bipolar disorder, a family member with bipolar disorder, or ever had an abnormally high mood (mania)
  • Ever tried to commit suicide, or have had thoughts of suicide or of harming yourself
  • Breast cancer or a history of it
  • Low blood sodium levels (hyponatremia)
  • Osteoporosis or have broken a bone
  • Glaucoma
  • Ever had bleeding problems
  • Any allergies, including to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
Make sure to tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
(Click Warnings and Precautions With Paroxetine Mesylate Capsules to learn more, including information on who should not take the drug.)

How Does This Medication Work?

As mentioned, paroxetine mesylate capsules belong to a class of medicines called selective serotonin reuptake inhibitors (SSRIs). SSRIs work to increase serotonin activity by increasing the amount of serotonin available in the small space between the cells in the body.
Serotonin has many functions in the body, including effects on mood and behavior. It is unknown how paroxetine mesylate capsules work to reduce hot flashes, but it is likely related to the drug's effects on serotonin. It is thought that changes in serotonin levels somehow contribute to the development of hot flashes during menopause.
The ability of SSRIs to reduce hot flashes is independent of their effects on mood. This is the reason paroxetine mesylate capsules work to treat hot flashes in doses that are lower than those needed to treat depression or anxiety.
Last reviewed by: Kristi Monson, PharmD
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