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Drug Interactions With Phendimetrazine

Phendimetrazine Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when phendimetrazine is combined with any of the drugs listed above.
Alcohol
Drinking alcohol while on phendimetrazine may increase the risk of side effects. Ask your healthcare provider if you should avoid alcohol while taking this medication.
Diabetes Medications
Because you may eat less while taking phendimetrazine (because the drug is an appetite suppressant), your healthcare provider may need to decrease the dose of your diabetes medications.
Monoamine Oxidase Inhibitors
Taking phendimetrazine and MAOIs together can cause life-threatening side effects, such as very high blood pressure. Do not take phendimetrazine if you have taken an MAOI within the past 14 days.
Sodium Bicarbonate
Sodium bicarbonate (when taken as a medication, not in normal food use) can increase the level of phendimetrazine in your blood, possibly increasing your risk of side effects of phendimetrazine. Check with your healthcare provider before taking these medications together.
Stimulants or Other Appetite Suppressants
Phendimetrazine should never be combined with other stimulants or appetite suppressants, due to the risk of dangerous side effects.
Tricyclic Antidepressants
Taking phendimetrazine with a tricyclic antidepressant can increase the risk of dangerous side effects from either medication. Check with your healthcare provider before combining these two medications.
Tromethamine
Tromethamine can increase the level of phendimetrazine in your blood, possibly increasing the risk of side effects. Talk with your healthcare provider before taking these medications together.
Last reviewed by: Kristi Monson, PharmD
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