Drug Interactions With Phendimetrazine

Drug interactions with phendimetrazine can occur if it is combined with other medications, such as diabetes medications, MAOIs, or tricyclic antidepressants. These may have serious consequences. For example, taking phendimetrazine within two weeks of taking an MAOI can result in life-threatening side effects. Also, some drug interactions with phendimetrazine can increase the amounts of the medications in your blood and may increase your risk of side effects.

An Introduction to Drug Interactions With Phendimetrazine

Phendimetrazine tartrate (Bontril®) can potentially interact with a few other medicines. Some of the medicines that may lead to drug interactions with phendimetrazine include:
  • Sodium bicarbonate medications (not food products)
  • Stimulants or any other medications that suppress the appetite 
  • Tricyclic antidepressants, such as:
  • Tromethamine (THAM®).
Last reviewed by: Kristi Monson, PharmD
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