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Phentermine and Topiramate Dosage

Your healthcare provider will recommend a dose of phentermine and topiramate that is individualized just for you, based on your medical history and how you respond to this diet medication. It comes as a capsule that is taken once daily in the morning. In many cases, the starting amount is 3.75 mg/23 mg once daily. However, this dose can be increased slowly as needed.

An Introduction to Your Dosage of Phentermine and Topiramate

The dose of phentermine and topiramate (Qsymia®) your healthcare provider recommends will vary, based on several factors, including:
 
  • How you respond to the medication
  • Other medical conditions you may have.
 
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.
 

Recommended Phentermine and Topiramate Dosing Guidelines

The usual starting dosage of phentermine and topiramate for weight loss is 3.75 mg/23 mg once a day in the morning for 14 days. After 14 days, the dosage is usually increased to 7.5 mg/46 mg once a day.
 
If you haven't lost at least 3 percent of your original weight after taking 7.5 mg/46 mg for 12 weeks, your healthcare provider will either recommend you stop taking the medication, or increase your dosage. If your dosage is increased, it will usually be increased in two steps: first, to 11.25 mg/69 mg once a day for 14 days, and then 15 mg/92 mg once a day thereafter.
 
If you haven't lost at least 5 percent of your original weight after taking 15 mg/92 mg for 12 weeks, your healthcare provider will likely recommend you stop treatment with phentermine and topiramate. At this point, it is unlikely the medication will work for you.
 
People who have moderate-to-severe kidney disease or moderate liver disease should not be treated with doses higher than 7.5 mg/46 mg once a day.
 
If you need to stop taking 15 mg/92 mg, your healthcare provider will slowly reduce your dosage. It is usually recommended that people take one dose every other day for at least a week before stopping the medicine altogether. Stopping it too quickly could lead to seizures.
 

More Headlines in Phentermine and Topiramate Dosage

‣ General Information on Taking Phentermine and Topiramate
Last reviewed by: Kristi Monson, PharmD
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