What Is Phentermine and Topiramate Used For?

How Does It Work?

As mentioned, this diet pill contains two medications, phentermine and topiramate. Phentermine is a weight loss medicine that is chemically related to amphetamines. It is thought to primarily work by increasing the release of certain naturally occurring substances in the hypothalamus, a part of the brain that helps control appetite. This action helps to suppress appetite, and decrease the amount of food a person eats.
It is not entirely clear how topiramate, the other active ingredient in the drug, helps with weight loss. It is thought that the medication primarily works in the brain to suppress appetite and enhance feelings of fullness.  

Can Children Use This Medicine?

Phentermine and topiramate has not been adequately studied in children, and is not approved for use in individuals younger than 18 years of age. Topiramate, one of the active ingredients in the drug, has caused potentially serious side effects in children, including:
  • Glaucoma (an eye condition)
  • Decreased sweating and fever
  • Metabolic acidosis (a potentially serious problem that occurs when there is too much acid in the blood)
  • Problems with mood and thinking
  • Brain problems
  • Kidney stones.
Talk to your healthcare provider about the risks and benefits of using this medicine in children.  

Is It Safe for Older Adults to Use Phentermine and Topiramate?

There were not enough older adults in phentermine and topiramate clinical trials to say for certain whether older adults will respond to or tolerate this medicine any differently than younger individuals. In general, this medication should be used cautiously in older adults. Lower doses may be needed, especially in older adults with kidney or liver disease.

More Headlines in What Is Phentermine and Topiramate Used For?

↶ An Overview of Uses for Phentermine and Topiramate
‣ What About Off-Label Uses?
Last reviewed by: Kristi Monson, PharmD
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