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Polidocanol Dosage

When treating certain types of varicose veins, the standard dose of polidocanol is between 0.1 mL and 0.3 mL. The total amount given should not exceed 10 mL. If more medication is required, additional treatment sessions should be scheduled, separated by at least one to two weeks. Compression stockings will likely be required for a few days after treatment, and certain activities should be avoided.

An Introduction to Dosing With Polidocanol

The standard dose for polidocanol (Asclera™) varies, depending on the type of vein(s) being treated. Reticular veins are treated with a higher concentration of polidocanol, compared to spider veins.

Standard Polidocanol Dosage

Spider veins are treated with polidocanol 0.5%, and reticular veins are treated with polidocanol 1%. For either type of vein, 0.1 to 0.3 mL is injected into each vein, with no more than 10 mL total used per treatment session (the smallest effective amount should be used in order to reduce the risk of side effects of polidocanol).
If more than 10 mL would be necessary to treat all the affected veins, more than one treatment session will be necessary. Wait at least one to two weeks in between treatment sessions.
Your healthcare provider will use a fine needle and should inject the medication slowly and carefully. Accidentally injecting polidocanol into an artery instead of a vein or letting it leak outside of a vein can lead to severe skin and tissue damage (this typically happens when too much polidocanol is injected too quickly).
Sometimes, small, hard blood clots form in the treated veins. These usually go away, but sometimes they need to be removed by making a small incision in the skin and draining the clotted blood.

General Information on Treatment With Polidocanol

Considerations to keep in mind when using polidocanol include the following:
  • Your healthcare provider will inject this medication directly into the affected veins.
  • Right after the injection, compression (typically in the form of compression stockings or support hose) should be used. The compression should be continued for two to seven days (depending on the severity of the veins), or perhaps longer in more severe cases. Compression is necessary to reduce the risk of deep vein thrombosis (DVT).
  • Ask your healthcare provider if you will need thigh-high or knee-high compression stockings or support hose.
  • It is best if you can walk for 15 to 20 minutes after the treatment session and daily for a few days thereafter.
  • For two to three days after treatment, avoid heavy exercise, sunbathing, long plane flights, and hot baths or saunas.
  • Make sure your healthcare provider is adequately qualified for this type of treatment; careless or improper injection technique can lead to dangerous complications.
  • If you are unsure about anything related to your polidocanol dosage, please talk with your doctor, nurse, or pharmacist.
Last reviewed by: Kristi Monson, PharmD
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