Precautions and Warnings With Polidocanol

Blood clots are a possible risk with polidocanol; however, you can avoid this complication by following your healthcare provider's instructions post treatment. Wear compression stockings as directed, and follow his or her guidelines regarding your activity level. Following these simple precautions and warnings with polidocanol can help ensure your safety during treatment.

What Should I Tell My Healthcare Provider?

Prior to taking polidocanol (Asclera™), tell your healthcare provider if you have:
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
Make sure to tell your healthcare provider about any other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Polidocanol Warnings and Precautions

Warnings and precautions to be aware of prior to taking this medication include the following:
  • In rare cases, polidocanol can cause severe allergic reactions. Your healthcare provider should not let you leave the office for a short while in order to make sure such reactions do not occur. Before giving an injection, your healthcare provider should be prepared to deal with a severe, life-threatening allergic reaction.
  • Polidocanol can damage tissues if accidentally injected into an artery instead of a vein or if it leaks outside a vein, which usually occurs if too much is injected too quickly. If this happens, you may need to see a specialist (such as a vascular surgeon) right away to help limit severe damage.
  • In rare cases, sclerotherapy treatment (such as treatment with polidocanol) can lead to dangerous blood clots. However, minor clots in the surface veins are more common and are typically not dangerous.
  • You will need to wear compression stockings or support hose after treatment. Make sure your healthcare provider explains exactly which type of compression you need and how long you should wear it.
  • Try to walk for 15 to 20 minutes after the injection (and daily for a few days thereafter). This helps to limit blood clot formation.
  • For two to three days after treatment, avoid heavy exercise, sunbathing, long plane flights, and hot baths or saunas.
  • Polidocanol is considered a pregnancy Category C medication. This means that it might be unsafe for use during pregnancy, although the full risks are not currently known (see Asclera and Pregnancy).
  • It is unknown if this medication passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to beginning treatment (see Asclera and Breastfeeding).

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Last reviewed by: Kristi Monson, PharmD
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