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Side Effects of Polidocanol

Reported Side Effects

Polidocanol has been studied thoroughly in clinical trials. In these studies, polidocanol was compared to both another sclerosing agent (sodium tetradecyl sulfate) and to a placebo (an injection with no active ingredients). This way, it was possible to observe the side effects that occurred with polidocanol and how they compared with side effects of sodium tetradecyl sulfate or the placebo.
In these studies, reported polidocanol side effects included:
  • Bruising at the injection site -- in up to 42 percent of people
  • Irritation at the injection site -- up to 41 percent
  • Discoloration at the injection site -- up to 38 percent
  • Injection site pain -- up to 24 percent
  • Injection site itching -- up to 19 percent
  • Injection site warmth -- up to 16 percent
  • New blood vessel growth -- up to 8 percent
  • Blood clots at the injection site -- up to 6 percent.
Blood clots at the injection site can usually be treated (if necessary) by making a small incision in the skin and draining the lumps of clotted blood. These blood clots are not usually dangerous, as they occur in surface blood vessels, not in deeper vessels.

Final Thoughts

You may experience some or none of the polidocanol side effects listed in this article. Unfortunately, there is no way for your healthcare provider to know beforehand if you will have problems with a medicine that you have never tried.
Therefore, make sure to let your healthcare provider know if you develop any side effects during treatment or if something "just does not seem right." While it may not be related to the medication, your healthcare provider will be able to diagnose and treat the problem.

More Headlines in Side Effects of Polidocanol

↶ An Introduction to Polidocanol Side Effects
↶ Serious Side Effects
Last reviewed by: Kristi Monson, PharmD
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