Drug Interactions With Portia

Many medications, including numerous seizure medications, barbiturates, and protease inhibitors, may potentially cause drug interactions with Portia. These interactions can increase your risk of developing side effects or increase your chance of unintentional pregnancy. If you are ever unsure about any Portia drug interaction, it is a good idea to use backup contraception until you can talk to your healthcare provider.

An Introduction to Portia Drug Interactions

Portia® (levonorgestrel/ethinyl estradiol) is a generic version of Nordette®. It can potentially interact with several other medicines. Sometimes, these interactions can be severe enough to increase the risk of unintentional pregnancy, in which case a backup method of birth control is usually recommended. If you do not know what to do about any particular Portia drug interaction, it is a good idea to use backup birth control until you can speak with your healthcare provider, just in case. Some of the medicines that may lead to Portia interactions include:
  • Aminoglutethimide (Cytadren®)
  • Antibiotics
  • Aprepitant (Emend®)
  • Barbiturate medications, including (but not limited to):


    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Primidone (Mysoline®)
    • Secobarbital (Seconal®)


  • Protease inhibitors, such as:


Last reviewed by: Kristi Monson, PharmD
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