Drug Interactions With Progesterone Capsules

Antibiotics, primidone, and barbiturates are among the medications that can interact with progesterone capsules. Drug interactions can reduce the effectiveness of progesterone capsules in some cases; they can also affect the way your body metabolizes this medication, which can lead to high progesterone levels. To reduce your risk of drug interactions with progesterone capsules, talk to your doctor about all other medications you are taking.

An Introduction to Drug Interactions With Progesterone Capsules

Progesterone capsules (Prometrium®) can potentially interact with several other medications. Some of the medicines that may lead to drug interactions with progesterone capsules include:
  • Aminoglutethimide (Cytadren®)
  • Antibiotics or antifungal medications
  • Barbiturate medications, including but not limited to:
    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Primidone (Mysoline®)
    • Secobarbital (Seconal®)

More Information on Interactions With Progesterone Capsules

The following sections explain in detail the potentially negative interactions that can occur when progesterone capsules are combined with any of the drugs listed above.
Aminoglutethimide (Cytadren)
Combining progesterone capsules with aminoglutethimide may make progesterone capsules less effective. Talk with your healthcare provider before using these medications together. You may need to use a backup method of contraception, such as condoms.

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Last reviewed by: Kristi Monson, PharmD
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