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Side Effects of Progesterone Capsules

The most common side effects of progesterone capsules include cramping, breast pain, and viral infections. Side effects of the drug are generally minor; however, there are also some potentially dangerous side effects that may occur in women using the drug. If you develop any serious progesterone capsules side effects, such as vision changes or depression, contact your healthcare provider right away.

An Introduction to Side Effects of Progesterone Capsules

Just like any medicine, progesterone capsules (Prometrium®) can cause side effects. However, not everyone who takes the medication will experience side effects. In fact, most women tolerate it quite well. If progesterone capsules side effects do occur, in most cases, they are minor and either require no treatment or are easily treated by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with progesterone capsules. Your healthcare provider can discuss a more complete list of progesterone capsules side effects with you.)

Serious Progesterone Capsules Side Effects

Some side effects with progesterone capsules are potentially serious and should be reported immediately to your healthcare provider. These include but are not limited to:
  • Depression
  • Severe dizziness or fainting, especially upon standing
  • Breast cancer
  • Gallbladder disease
  • Fluid retention (water weight gain)
  • Any vision changes
  • Signs of an allergic reaction, including:
    • An unexplained rash
    • Hives
    • Itching
    • Unexplained swelling
    • Wheezing
    • Difficulty breathing or swallowing.
Because of the potentially serious nature of these side effects, there are a few symptoms you should watch for and report to your healthcare provider immediately if they occur. These include but are not limited to:
    • Vision or speech changes
    • Weakness or numbness in an arm or leg
    • Severe headache
  • Signs of liver damage, such as:
    • Yellowing of the whites of the eyes or skin (jaundice)
    • Dark urine
    • Upper-right abdominal pain (stomach pain)
  • Migraines (or changes in your migraines, if you have had them before)
  • Breast lumps
  • Signs of a blood clot in the leg, such as:
    • Pain in the calf
    • Leg cramps
    • Leg or foot swelling
  • Signs of a blood clot in the lung, such as:
    • Shortness of breath
    • Sharp chest pain
    • Coughing up blood
  • Chest pain or heaviness, which may be signs of a heart attack
  • Sudden loss of vision or vision changes, which can be a sign of a blood clot in the eye
  • Heavy or unexpected vaginal bleeding.
Last reviewed by: Kristi Monson, PharmD
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