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Proquin XR and Tendon Rupture

Although rare, problems such as tendonitis and tendon rupture are possible with Proquin XR. In some cases, tendon problems have even been reported several months after treatment has stopped. Due to the potentially serious nature of these problems, it's important to watch for any signs or symptoms (such as weakness or tendon pain) and notify your healthcare provider immediately if they occur.

An Overview of Tendon Rupture With Proquin XR

Proquin® XR (ciprofloxacin hydrochloride) is an antibiotic used to treat a certain type of urinary tract infection, commonly called a bladder infection. It belongs to a group of drugs called fluoroquinolones, or "quinolones" for short. Like all quinolones, the use of Proquin XR is associated with tendon problems, such as tendonitis and tendon rupture.

Why Can Proquin XR Cause Tendon Rupture?

Tendons are tissues in the body that connect muscles to bone. Tendonitis is a medical term that refers to inflammation or swelling of a tendon. A tendon rupture happens when a tendon breaks or tears apart. These ruptures are often extremely painful, and may lead to permanent damage if not promptly treated.
The United States Food and Drug Administration (FDA) issued a special warning, called a "black box warning," for all fluoroquinolones, including Proquin XR. This warning describes the increased risk for tendonitis and tendon rupture with fluoroquinolone treatment. Although tendon problems occur rarely, they can be serious. Early recognition and treatment is important to prevent further tendon damage.
The most common type of tendon rupture with fluoroquinolone use is a rupture of the Achilles tendon. The Achilles tendon connects the heel to the lower leg muscles. When it ruptures, it may need to be surgically repaired. Tendonitis and tendon rupture have also been reported in other joint areas, including:
  • Shoulder
  • Hand
  • Thumb
  • Biceps.
Last reviewed by: Kristi Monson, PharmD
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