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Proquin XR Drug Interactions

QT-Prolonging Medications
In general, Proquin XR should be used with caution with any other medications that can cause QT prolongation (a certain change in the heart rhythm). Taking Proquin XR with these medications may increase the risk of a life-threatening arrhythmia. Talk to your healthcare provider about this interaction if you take any QT-prolonging drugs.
Methotrexate
Proquin XR may increase the amount of methotrexate in your blood, increasing your risk for potentially serious side effects. If you take these medications together, your healthcare provider may need to monitor you closely for methotrexate toxicity.
Mycophenolate
Proquin XR may reduce the amount of mycophenolate in your blood, potentially decreasing its effectiveness. If you take these medications together, your healthcare provider may need to monitor you more closely to make sure mycophenolate is working for you.
NSAIDs
There have been reports of seizures in clinical trials when NSAIDs were given in combination with high doses of medications like Proquin XR. Check with your healthcare provider before taking Proquin XR with an NSAID.
P-glycoprotein Inducers
P-glycoprotein (Pgp) is a protein found in the body. One of its roles is to help remove substances such as medications from the body. Proquin XR is one of the drugs partly removed from the body by Pgp. Certain other medications are Pgp inducers. This means they increase the action of Pgp. Taking Proquin XR with a Pgp inducer may decrease the amount of Proquin XR in your blood, potentially making it less effective.
Your healthcare provider may need to monitor you more closely if you take Proquin XR with a Pgp inducer to make sure your infection is completely resolved.
Last reviewed by: Kristi Monson, PharmD
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