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Proquin XR Drug Interactions

P-glycoprotein Inhibitors
P-glycoprotein (Pgp) is a protein found in the body. One of its roles is to help remove substances such as medications from the body. Proquin XR is one of the medications partly removed from the body by Pgp. Certain other medications are Pgp inhibitors. This means they decrease the action of Pgp. Taking Proquin XR with a Pgp inducer may increase the amount of Proquin XR in your blood, potentially increasing your risk for side effects.
Your healthcare provider may need to monitor you more closely if you take Proquin XR with a Pgp inhibitor.
Pentoxifylline
Proquin XR may increase the amount of pentoxifylline in your body, potentially increasing your risk for pentoxifylline side effects, such as headaches. Let your healthcare provider know if you develop bothersome headaches if taking these medications together.
Phenytoin
Proquin XR may decrease or increase the amount of phenytoin in your body, potentially making that drug less effective or increasing your risk for side effects. In addition, your risk for seizures may be increased. Talk to your healthcare provider about this drug interaction if you take phenytoin.
Probenecid
Taking probenecid with Proquin XR may increase the amount of Proquin XR in your blood, increasing your risk for side effects. Be especially watchful for Proquin XR side effects if you take these medications together.
Quinapril
Quinapril can bind to Proquin XR in the digestive tract, preventing it from being absorbed into the bloodstream. Separate your Proquin XR and quinapril doses by at least two hours to help minimize the chance of this interaction.
Ropinirole
Proquin XR may increase the amount of ropinirole in your body, increasing your risk for side effects. Your healthcare provider may choose to monitor you more closely for side effects of ropinirole if you take these medications together.
Last reviewed by: Kristi Monson, PharmD
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