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Proquin XR Warnings and Precautions

Specific Precautions and Warnings With Proquin XR

Some warnings and precautions to be aware of prior to taking this drug include the following:
  • Proquin XR may cause tendon problems, including tendon rupture. People who are over the age of 60; who have had liver, lung, or heart transplants; or who take corticosteroid drugs are at an increased risk for these problems. 
Contact your healthcare provider right away if you have any tendon pain, soreness, or swelling, or if you experience weakness or difficulty moving any of your joints. Do not exercise until your healthcare provider makes sure you do not have a ruptured tendon. (Click Proquin XR and Tendon Rupture for more information.)
  • Proquin XR can cause a severe allergic reaction. Contact your healthcare provider immediately if you develop any signs of an allergic reaction, such as:
    • Rash
    • Hives
    • Itching
    • Swelling of the lips or throat
    • Wheezing
    • Difficulty breathing.
  • Central nervous system problems and neurological side effects have been reported with Proquin XR use, sometimes even after just one dose. Such problems may include:
    • Seizures
    • Tremors
    • Confusion
    • Dizziness
    • Hallucinations
    • Paranoia
    • Anxiety
    • Depression
    • Nervousness
    • Agitation
    • Nightmares
    • Suicidal thoughts or acts.
Certain conditions, including epilepsy, cerebral arteriosclerosis, and kidney disease, can increase your risk of developing these problems.
  • Proquin XR may cause a rare and potentially dangerous problem with the heart rhythm known as QT prolongation. QT prolongation may be more common in older adults, people with low blood potassium, or those taking certain other medications (see Proquin XR Drug Interactions).
  • Proquin XR (as well as all other fluoroquinolone antibiotics) can cause worsening of myasthenia gravis symptoms, such as muscle weakness and breathing problems. This is a serious occurrence, which can be life-threatening. In severe cases, this can result in the need to be put on a ventilator, or even death. Proquin XR should be avoided in people with a known history of myasthenia gravis
  • People with diabetes who are taking medications called sulfonylureas may experience high or low blood sugar while taking Proquin XR (see Proquin XR Drug Interactions). If you have diabetes, you may need to monitor your blood sugar more closely while taking this medicine.
  • Sun sensitivity has been reported with Proquin XR use. Try to avoid sun exposure, including natural sun and tanning beds, while taking this medication. If you do go out in the sun, wear protective clothing and sunscreen. Contact your healthcare provider if you develop a severe sunburn while taking Proquin XR.
  • This medicine has been reported to cause a nerve problem called peripheral neuropathy. If you develop any unusual sensations while taking it, such as pain, burning, tingling, prickling, or weakness, contact your healthcare provider right away to reduce the chance of permanent nerve damage.
  • You may become dizzy or lightheaded while taking Proquin XR. Therefore, you should avoid driving or doing anything that requires mental alertness until you know how you will react to this medicine.
  • Antibiotics like Proquin XR can alter the normal bacteria in the digestive tract, allowing an overgrowth of undesirable bacteria known as Clostridium difficile. This overgrowth can lead to a serious and potentially life-threatening problem called pseudomembranous colitis.
Tell your healthcare provider if you experience bloody or watery diarrhea while taking Proquin XR, or in the few months after you stop the medication. Although mild, short-term diarrhea is a common side effect of antibiotic use, bloody or watery diarrhea may be signs of pseudomembranous colitis.
  • This product may react with several other medications (see Proquin XR Drug Interactions).
  • Proquin XR is a pregnancy Category C medication, which means that it may not be safe for use during pregnancy, although the full risks are currently unknown (see Proquin XR and Pregnancy for more information).
  • Proquin XR passes through breast milk. Therefore, if you are breastfeeding or plan to start, check with your healthcare provider before using this drug (see Proquin XR and Breastfeeding).
Last reviewed by: Kristi Monson, PharmD
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