Prostin E2 and Breastfeeding

It is unknown whether Prostin E2 (dinoprostone vaginal suppository) passes through breast milk or if it would harm a nursing infant. However, this drug is approved to terminate a pregnancy or to treat a cancer-like condition of the uterus, and it is unlikely that a woman would receive Prostin E2 while breastfeeding.

Can Breastfeeding Women Use Prostin E2?

It is currently unknown whether Prostin E2® (dinoprostone vaginal suppository) passes through breast milk in humans. If you are breastfeeding, talk with your healthcare provider before receiving this drug.

More Information on Prostin E2 and Breastfeeding

There is currently no research on the use of Prostin E2 in breastfeeding women or animals. Therefore, it is unknown whether the medication passes through breast milk, or whether it would harm a nursing child.
Prostin E2 is a hormone-type substance known as a prostaglandin. Prostaglandins are naturally found in breast milk in small amounts, where they are thought to help protect the infant's gastrointestinal tract.
When given by mouth in the first few days after birth, dinoprostone (the active ingredient in Prostin E2) can suppress milk production. However, by one month after birth, the drug no longer has an effect on lactation.
Prostin E2 is used in pregnant women who want to terminate their pregnancy. It is also used for a cancer-like condition of the uterus. Based on its normal uses, this medication is unlikely to be used in the first few days after birth or in women who are breastfeeding.

Talking With Your Healthcare Provider

You should discuss breastfeeding and Prostin E2 use with your healthcare provider. Each woman's situation is different, and you and your healthcare provider understand your situation best. After considering what you want and expect, as well as your current health situation, the two of you can make a shared decision that is right for you.
Last reviewed by: Kristi Monson, PharmD
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