Prostin E2 Uses

A healthcare provider may prescribe Prostin E2 to a woman for several reasons, such as to terminate a pregnancy, remove the fetus and placenta after a missed abortion, and treat nonmetastatic gestational trophoblastic disease. This medicine is a synthetic version of a naturally occurring substance needed to help prepare the body for delivery. Prostin E2 is approved for use in adults only.

What Is Prostin E2 Used For?

Prostin E2® (dinoprostone vaginal suppository) is a prescription medication approved for the following uses:
  • Terminating a pregnancy in weeks 12 through 20
  • Removing the contents of pregnancy after a "missed abortion" or "missed miscarriage"
  • Treating a condition of the uterus known as nonmetastatic gestational trophoblastic disease or benign hydatidiform mole.
A miscarriage is the term used to describe a pregnancy that ends on its own within the first 20 weeks. It may also sometimes be called a spontaneous abortion. When a pregnancy spontaneously ends after week 20, it may be referred to as an intrauterine fetal death. There are numerous reasons why a pregnancy may not carry to term, and unfortunately many times an exact reason cannot be found.
When a pregnancy loss occurs, it is important that all of the contents of conception, including the fetus and placenta, are removed from the womb. Any remaining tissue can be harmful to a woman's health, increasing the risk for potentially serious problems, including infection and bleeding.
A missed abortion or missed miscarriage is the term used to describe the loss of pregnancy in which the contents of the womb (the uterus) do not exit the body. Typically, in this situation, a woman finds out a miscarriage has occurred when an ultrasound shows that the fetus has died. Prostin E2 is used to remove any remaining material from the uterus after a missed abortion or intrauterine fetal death up to 28 weeks of pregnancy.
Although the word "abortion" is often used to describe a miscarriage, it is important to recognize that a spontaneous abortion is not the same as a medical or surgical abortion. A medical or surgical abortion is the elective termination of pregnancy. Choosing to end a pregnancy is a very personal decision. A woman who is considering pregnancy termination should find a safe place to explore her options.
Once a decision is made, a variety of procedures may be used to terminate a pregnancy. The option chosen will depend largely on how far along the woman is in her pregnancy. Prostin E2 is approved to cause an abortion during weeks 12 through 20 of pregnancy.
Prostin E2 is also used to treat a condition known as nonmetastatic gestational trophoblastic disease (also called benign hydatidiform mole). This condition is a cancer-like disease in which cancer cells grow in the tissue that formed as a result of conception. In some cases, the cancer cells can spread to other parts of the body. However, hydatidiform mole or nonmetastatic disease does not spread beyond the uterus.
Last reviewed by: Kristi Monson, PharmD
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