Provera Drug Interactions

Taking certain drugs with Provera can cause negative interactions. Some of these medications can interfere with how the liver breaks down Provera, which may decrease the effectiveness of the drug or increase your risk for side effects. Cyclosporine, thyroid medicines, and certain medications that affect liver enzymes can cause problems when used with Provera.

Provera Medication Information

An Overview of Interactions With Provera

Provera^® (medroxyprogesterone acetate) is a female hormone similar to progesterone, a natural hormone made by the body. It is used in women who are having irregular periods or no periods at all, or in certain postmenopausal women who are taking estrogen. Provera may react with a number of other medications.

Some of the drugs that may lead to interactions with Provera include but are not limited to:

Cyclosporine (Gengraf^®, Neoral^®, Sandimmune^®)
CYP 3A4 inducer medications, such as:

Aminoglutethimide (Cytadren^®)
Bosentan (Tracleer^®)
Carbamazepine (Carbatrol^®, Epitol^®, Equetro^®, Tegretol^®)
Dexamethasone (Decadron^®, Dexpak^®, Maxidex^®)
Efavirenz (Sustiva^®)
Efavirenz, emtricitabine, and tenofovir (Atripla^®)
Etravirine (Intelence™)
Fosphenytoin (Cerebyx^®)
Nafcillin
Nevirapine (Viramune^®)
Oxcarbazepine (Trileptal^®)
Pentobarbital (Nembutal^®)
Phenobarbital (Luminal^®)
Phenytoin (Dilantin^®, Phenytek^®)
Primidone (Mysoline^®)
Rifabutin (Mycobutin^®)
Rifampin (Rifadin^®)
Rifapentine (Priftin^®)
St. John's wort

Thyroid medications, such as:

Liothyronine (Cytomel^®)
Liotrix (Thyrolar^®)
Levothyroxine (Levothroid^®, Levoxyl^®, Synthroid^®, Tirosint^®, Unithroid^®)
Thyroid (Armor^® Thyroid, Nature-Throid^®, Westhroid^®).

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