Provera Side Effects

While only vague information is available about the possible side effects of Provera, adverse reactions may include headaches, breast tenderness, and breakthrough bleeding or spotting. In most cases, reactions to this drug tend to be minor. However, contact your healthcare provider immediately if you experience vision or speech changes, sudden chest pain, or numbness in an arm or leg.

An Introduction to Provera Side Effects

Just like any medicine, Provera® (medroxyprogesterone acetate) can cause side effects. However, not everyone who takes the medication will have problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with Provera. Your healthcare provider can discuss a more complete list with you.)

Common Side Effects of Provera

For many medications, the prescribing information carefully explains the exact percentage of side effects that were seen in clinical trials. However, the prescribing information for almost all older medications, including Provera, includes only vague information on potential side effects, with no exact percentages provided. Therefore, it can be difficult to know exactly how frequently side effects occur.
Based on the side effects reported in women taking progestin hormones, including Provera, possible adverse reactions may include but are not limited to:
  • Irregular menstrual periods
  • Spotting
  • Breast tenderness or pain
  • Headache
  • Vaginal bleeding, such as breakthrough bleeding or spotting
  • An absence of menstrual periods (amenorrhea)
  • Vaginal secretions
  • Nervousness
  • Depression
  • Dizziness
  • Drowsiness or fatigue
  • Insomnia
  • Acne
  • Rash and Itching
  • Abdominal (stomach) pain
  • Nausea
  • Bloating
  • Swelling
  • Fever
  • Weight gain or weight loss
  • Milky secretion from the nipples (galactorrhea)
  • Loss of hair or increased hair growth.

More Headlines in Provera Side Effects

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Last reviewed by: Kristi Monson, PharmD
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