Provera Uses

Provera Use for Abnormal Uterine Bleeding

Abnormal uterine bleeding is any irregular vaginal bleeding, or irregular periods. It is usually due to a change in hormone levels. Abnormal uterine bleeding can include any of the following changes in a woman's period:
  • Bleeding or spotting between periods
  • Shorter or longer menstrual cycles than normal
  • Heavy menstrual bleeding
  • Bleeding for more days than normal.
Provera is approved to treat irregular bleeding caused by hormonal imbalances. It is not approved for use in treating irregular bleeding due to other causes, such as uterine growth (fibroids) or cancer.

Using Provera for Endometrial Hyperplasia

Some women take estrogen to help relieve symptoms of menopause. If estrogen is given to women who have not had a hysterectomy (women who still have their uterus), endometrial hyperplasia can occur. This can increase the risk for cancer of the uterus.
Endometrial hyperplasia is a condition in which the lining of the uterus (the endometrium) grows too thick. Although endometrial hyperplasia is not cancerous in and of itself, in some cases it can lead to cancer of the uterus, which is also called endometrial cancer.
Provera can prevent this thickening of the endometrium, thereby preventing endometrial hyperplasia and reducing the risk for uterine cancer. Using hormones such as Provera in combination with estrogen is called combination hormone therapy, or combination HT. Combination HT is only necessary for women who still have a uterus. Women who have had a hysterectomy may receive estrogen alone.
Combination HT is associated with a variety of health risks, such as heart disease, stroke, and dementia. Because of these risks, it is recommended that this type of therapy be used at the lowest effective dose for the shortest time necessary. Women who are taking combination HT should be evaluated by their healthcare provider on a regular basis to assess whether they need to continue treatment.
Last reviewed by: Kristi Monson, PharmD
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