Provera Uses

Containing a manufactured form of progestin, Provera is approved for use in restoring regular menstrual cycles in women with amenorrhea or abnormal uterine bleeding. It can also be used in combination with estrogen to relieve postmenopausal symptoms in women who have not had a hysterectomy. There are also off-label uses for Provera, including the treatment of endometriosis or symptoms of certain types of cancer.

What Is Provera Used For?

Provera® (medroxyprogesterone acetate) is a prescription medication that contains medroxyprogesterone, a progestin hormone. It is approved for the following uses:
  • Treating amenorrhea (absence of a menstrual period) in women who previously had regular menstrual cycles but have not had a period for several months
  • Treating abnormal uterine bleeding due to an imbalance of hormones
  • Preventing endometrial hyperplasia (a condition in which the lining of the uterus grows too thick) in postmenopausal women who are taking estrogen, which can reduce the risk for uterine cancer.

Using Provera for Amenorrhea

Amenorrhea is the absence of a menstrual period. It is usually classified as primary or secondary. Primary amenorrhea occurs when a young women has not had a period by the time she is 16 years old. Secondary amenorrhea is when a woman who previously had regular menstrual periods stops having them for several months.
There are various reasons why a woman may stop having a period. Pregnancy, breastfeeding, and certain medications (such as some forms of birth control) are common causes of amenorrhea. Hormonal problems can also be a cause.
Provera is approved to treat secondary amenorrhea caused by an imbalance of hormones. When this drug is given for 5 to 10 days and then stopped, the endometrium sheds and vaginal bleeding occurs. This can help restore regular menstrual periods.
Last reviewed by: Kristi Monson, PharmD
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