Provera Warnings and Precautions

Specific Precautions and Warnings for Provera

Some warnings and precautions to be aware of prior to taking this medicine include the following:
  • Studies have shown that combination hormone therapy (combination HT) in which an estrogen is combined with a progestin (such as Provera) can increase the risk for heart attacks, strokes, breast cancer, dementia, and blood clots. Because of these risks, combination HT should be used at the lowest dose for the shortest time necessary. Talk to your healthcare provider on a regular basis (every three to six months) to determine if you still need combination HT.
  • Let your healthcare provider know if you experience abnormal vaginal bleeding, such as heavy bleeding, bleeding between periods, or bleeding after menopause. These could be signs of cancer of the uterus.
  • Certain things can increase your risk for heart disease, strokes, or blood clots, including:
Before starting Provera, talk to your healthcare provider about ways you can appropriately manage these conditions to help lower your risk.
  • Using estrogen plus a progestin may increase the risk for breast cancer and ovarian cancer. Women who use Provera should receive proper screening and monitoring, such as routine breast exams and mammograms. You may need to be monitored more closely if you have ever had an abnormal mammogram or breast lumps, or have a family history of breast cancer.
  • Contact your healthcare provider right away if you experience a sudden loss of vision, vision changes, or a migraine headache (or a worsening of migraines if you already get them). These could be signs of potentially serious problems.
  • Combination HT can increase the risk for breast cancer, high cholesterol, and impaired glucose tolerance (sometimes referred to as "prediabetes"). If you take Provera with estrogen, your healthcare provider will monitor you for these problems.
  • Provera can increase blood pressure and triglyceride levels. Your healthcare provider may monitor you for these problems during treatment.
  • If you have had jaundice (yellowing of the whites of the eyes or skin) in the past due to estrogen use or pregnancy, your healthcare provider may choose to monitor you more closely if you take Provera with an estrogen. If you experience jaundice again, you will likely need to stop taking Provera.
  • Your healthcare provider may need to monitor you more closely if you have a condition that could be affected by fluid retention. Provera can cause fluid retention, which may be a problem in people with medical conditions such as:
  • This drug should be used with caution in people with extremely low calcium blood levels (hypocalcemia).
  • Your healthcare provider may need to monitor you closely if you have certain chronic medical conditions, as Provera can make these conditions worse. Contact your healthcare provider if you have any of the following medical issues and your symptoms worsen:
  • This product passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Provera and Breastfeeding).
  • Provera is a pregnancy Category X medication. This means that it should not be taken by women who are pregnant (see Provera and Pregnancy).
Last reviewed by: Kristi Monson, PharmD
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