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Seasonale Drug Interactions

Seasonale Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Seasonale is combined with any of the drugs listed above.
Aminoglutethimide (Cytadren)
Aminoglutethimide can make Seasonale less effective, possibly increasing your risk of pregnancy. Talk with your healthcare provider before using these medications together. You may need to use a backup method of contraception, such as condoms.
Antibiotics
There have been reports of accidental pregnancy occurring in women taking birth control pills and certain antibiotics. However, the significance of this interaction is still uncertain. Some antibiotics may be more likely to cause problems than others. If you are taking an antibiotic, ask your healthcare provider if you need to use a backup method of contraception.
Aprepitant (Emend)
Aprepitant can make Seasonale less effective, perhaps increasing your chance of pregnancy. Talk with your healthcare provider before using these medications together. You may need to use a backup method of contraception.
Atorvastatin (Lipitor)
Atorvastatin may increase the level of Seasonale in your blood, which may increase your risk of Seasonale side effects. Check with your healthcare provider before taking these medications together.
Barbiturates
Barbiturates may cause your body to metabolize the hormones in Seasonale too quickly, possibly increasing your risk of pregnancy. Ask your healthcare provider if you should use a different method of contraception while taking a barbiturate.
Cyclosporine (Gengraf, Neoral, Sandimmune)
Seasonale may increase the level of cyclosporine in your blood, possibly increasing the chance of side effects of cyclosporine. Talk with your healthcare provider before taking these medications together. You may need a lower cyclosporine dose, or you may need to switch to a different method of contraception.
Last reviewed by: Kristi Monson, PharmD
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