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Seasonale Drug Interactions

Modafinil (Provigil)
Modafinil can make Seasonale less effective, possibly increasing your risk of pregnancy. Talk with your healthcare provider if you are taking both of these medications, as you may need to use a backup method of contraception.
Protease Inhibitors
Using Seasonale with a protease inhibitor may increase your risk of pregnancy and can make the protease inhibitor less effective. Talk with your healthcare provider before using these medications together.
Selegiline (Eldepryl, Emsam, Zelapar)
The hormones in Seasonale may increase the level of selegiline in your blood, which could increase your risk of side effects. Your healthcare provider may need to lower your selegiline dosage or may recommend an alternate form of contraception.
St. John's Wort
St. John's wort (a commonly used herbal supplement) may decrease the effectiveness of Seasonale, possibly increasing the chance of pregnancy. In general, you should not take St. John's wort while using Seasonale.
Theophylline (Uniphyl, Theocron, TheoCap, Theo-24, Elixophyllin)
Seasonale may increase the level of theophylline in your blood, possibly increasing the chance of theophylline side effects. Talk with your healthcare provider before taking these medications together. You may need a lower theophylline dose, or you may need to switch to a different method of contraception
Various Seizure Medications
Some seizure medications may cause your body to metabolize the hormones in Seasonale too quickly, which could increase your risk of pregnancy. Ask your healthcare provider if you should use a different method of contraception while taking a seizure medication.
Last reviewed by: Kristi Monson, PharmD
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