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Drug Interactions With Sibutramine

Sibutramine Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when sibutramine is combined with any of the drugs listed above.
Certain Antibiotics or Antifungals
Several antibiotics or antifungal medications can increase the level of sibutramine in your blood, increasing your risk of sibutramine side effects. Check with your healthcare provider before combining sibutramine with an antibiotic or antifungal medication.
Certain Pain Medications
Combining sibutramine and certain pain medications can cause a group of symptoms called serotonin syndrome. These symptoms include confusion, hallucinations, a fast heartbeat, feeling faint, fever, sweating, muscle spasms, difficulty walking, and diarrhea. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any of these symptoms, as serotonin syndrome can be very dangerous.
Cough and Cold Medications
Check with your healthcare provider before combining sibutramine with any cough, cold, or allergy medication (including non-prescription products). Many of these products contain medications that can cause dangerous interactions with sibutramine.
Ergot Medications
Taking sibutramine with ergot medications can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome (see above), as it can be very dangerous.
Lithium (Eskalith, Lithobid)
Taking sibutramine with lithium can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome (see above), as it can be very dangerous.
Last reviewed by: Kristi Monson, PharmD
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