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Drug Interactions With Sibutramine

Monoamine Oxidase Inhibitors (MAOIs)
Taking sibutramine and an MAOI together can cause life-threatening side effects. Never take an MAOI and sibutramine at the same time, and do not take them within two weeks of each other.
Other Weight-Loss Medications
Check with your healthcare provider before taking sibutramine with any other weight-loss medications. Sibutramine should not be taken with any other weight-loss medication that also affects certain brain chemicals.
SSRI or SNRI Medications
Taking sibutramine with SSRIs or SNRIs can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome (see above), as it can be very dangerous.
St. John's Wort
Taking sibutramine with St. John's wort can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome (see above), as it can be very dangerous.
Tricyclic Antidepressants
Taking sibutramine with tricyclic antidepressants can increase the level of tricyclic antidepressants in your blood. Your healthcare provider may need to reduce your dose of the tricyclic antidepressant.
Triptans
Taking sibutramine with a triptan migraine medication can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome (see above), as it can be very dangerous.
Last reviewed by: Kristi Monson, PharmD
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