Effects of Sibutramine

Studies have shown that sibutramine helps people lose weight. After six months of taking it while dieting, people lost up to 18 pounds, compared to just 2.9 pounds for people who were only dieting. Higher doses produced the greatest weight losses. Similar results were seen in a one-year study.
Clinical studies have also shown that sibutramine can help people who have already lost weight to keep the weight off. In one study, up to 43 percent of people taking the drug (plus dieting) were able to keep off at least 80 percent of their initial weight loss after two years, compared to only 3 percent of the people who were only dieting.
Studies have also shown that taking sibutramine (plus dieting) produced beneficial changes in cholesterol levels (most likely as a result of the weight loss). Total cholesterol, "bad" cholesterol (LDL), and triglyceride levels dropped, while "good" cholesterol (HDL) levels increased.

When and How to Take It

Some general considerations for when and how to take sibutramine include the following:
  • The medication comes in capsule form. It is taken by mouth once daily.
  • You can take sibutramine with or without food. If the medication bothers your stomach, try taking it with food.
  • Sibutramine should be combined with a low-calorie diet. It is not meant to be used without dieting.
  • For the medication to work properly, it must be taken as prescribed.

Who Makes Sibutramine?

Sibutramine is made by Abbott Laboratories.

Available Strengths

Sibutramine capsules come in the following strengths:
  • Sibutramine 5 mg
  • Sibutramine 10 mg
  • Sibutramine 15 mg.
Last reviewed by: Kristi Monson, PharmD
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